Gonadotropin-releasing hormone (GnRH) agonists are synthetic peptides that mimic the natural GnRH produced by the hypothalamus. These agents initially stimulate the release of gonadotropins (LH and FSH) from the pituitary gland but subsequently lead to a downregulation of GnRH receptors, ultimately reducing gonadotropin secretion and lowering sex hormone levels such as estrogen and progesterone.
