Platelet transfusions are not always the best course of action and should be avoided in certain scenarios, such as: - Autoimmune Thrombocytopenia: In cases of immune thrombocytopenic purpura (ITP), where the body destroys platelets, transfusions might be counterproductive. - Chronic Conditions: For chronic, stable thrombocytopenia without active bleeding, the risks of transfusions may outweigh the benefits.