While generally safe, platelet transfusions do carry some risks, including: - Allergic Reactions: Some patients may experience mild to severe allergic reactions. - Infections: Though rare, there is a risk of infections from transfused blood products. - Transfusion-Related Acute Lung Injury (TRALI): A serious but rare condition where the lungs are affected following a transfusion. - Platelet Refractoriness: In some cases, patients may become resistant to transfused platelets, usually due to the development of antibodies.