What is the Connection Between CGG Repeats and Premature Ovarian Insufficiency?
Women who carry the premutation of the FMR1 gene (55-200 CGG repeats) are at an increased risk of developing Premature Ovarian Insufficiency (POI), which is characterized by the loss of normal ovarian function before the age of 40. POI can lead to infertility, irregular menstrual cycles, and early menopause. It is estimated that approximately 20% of women with a premutation will develop POI.
