Yes, all painkillers come with potential side effects. For NSAIDs, common side effects include gastrointestinal issues like stomach pain, ulcers, and bleeding. Long-term use can increase the risk of cardiovascular events. Acetaminophen is generally safe but can cause liver damage if taken in excessive amounts. Opioids carry risks of addiction, constipation, and respiratory depression. Hormonal therapies can have side effects such as weight gain, mood changes, and increased risk of blood clots.