IVF with donor gametes is recommended in several situations: - Severe Male Factor Infertility: When the male partner’s sperm count or quality is too poor. - Premature Ovarian Failure: When a woman’s ovaries stop functioning before the age of 40. - Genetic Disorders: To avoid passing on genetic diseases. - Repeated IVF Failures: When previous IVF attempts with own gametes have failed. - Same-Sex Couples or Single Parents: Who require sperm or egg donation for conception.