The exact cause of POF is often unknown, but several factors can contribute to its development:
Genetic factors: Conditions like Turner syndrome and Fragile X syndrome are associated with POF. Autoimmune disorders: The body's immune system may mistakenly attack ovarian tissues. Environmental factors: Exposure to chemotherapy or radiation therapy can damage the ovaries. Infections: Certain viral infections can affect ovarian function. Surgical procedures: Removal of ovaries for medical reasons can result in POF.