Primary amenorrhea can be caused by a variety of factors, including:
- Genetic Disorders: Conditions like Turner's syndrome (45,XO) and Androgen Insensitivity Syndrome can lead to primary amenorrhea. - Anatomical Abnormalities: Congenital absence of the uterus, cervix, or vagina, known as Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome, can prevent menstruation. - Hormonal Imbalances: Disorders like Polycystic Ovary Syndrome (PCOS) and hypothalamic dysfunction can also cause primary amenorrhea. - Chronic Illnesses: Conditions such as diabetes and celiac disease can disrupt normal menstrual cycles. - Malnutrition and Eating Disorders: Severe undernutrition or eating disorders like anorexia nervosa can lead to hormonal imbalances that result in primary amenorrhea.
