How Does Cytochrome P450 Affect Contraceptive Efficacy?
Many oral contraceptives contain synthetic estrogens and progestins, which are metabolized by CYP450 enzymes. Variations in CYP450 activity can influence the effectiveness of these contraceptives. For instance, some medications and herbal supplements like St. John’s Wort can induce CYP450 enzymes, potentially reducing contraceptive efficacy and increasing the risk of unintended pregnancy.
