The mode of action of vaginal creams depends on their active ingredients. For instance, antifungal creams usually contain agents like clotrimazole or miconazole that disrupt the cell membranes of fungi, thereby killing them. Hormonal creams, often containing estrogen, help restore the vaginal lining and relieve symptoms of atrophic vaginitis. Moisturizing creams, on the other hand, help in maintaining vaginal moisture and flexibility.