Diuretics can influence hormonal balance in several ways. For instance, thiazide diuretics may increase calcium levels, which can be beneficial for women at risk of osteoporosis. However, they can also lead to electrolyte imbalances, which may affect menstrual cycles and overall hormonal health. Potassium-sparing diuretics like spironolactone have anti-androgenic properties and are often used to treat hirsutism and acne in women with PCOS.