Patients can manage co-insurance costs by choosing in-network providers, as insurance companies often cover a higher percentage of the costs for services rendered by these providers. Additionally, patients can take advantage of preventive care services, which are often fully covered by insurance, to catch health issues early and avoid more costly treatments later. It's also advisable to budget for co-insurance costs and use Health Savings Accounts (HSAs) or Flexible Spending Accounts (FSAs) to set aside pre-tax dollars for medical expenses.