T Cells - Gynecology

What are T Cells?

T cells, a type of white blood cell, play a crucial role in the immune system. They are primarily responsible for identifying and eliminating foreign pathogens, including viruses, bacteria, and cancer cells. These cells are part of the adaptive immune response and are essential for maintaining immune surveillance and homeostasis.

Role of T Cells in Gynecological Health

In gynecology, T cells are vital for maintaining the health of the female reproductive system. They help protect against infections, including sexually transmitted infections (STIs) like human papillomavirus (HPV) and herpes simplex virus (HSV). T cells also play a role in identifying and eliminating abnormal cells that could potentially develop into cancers, such as cervical cancer and ovarian cancer.

How Do T Cells Function?

T cells function through two main mechanisms: cytotoxicity and helper functions. Cytotoxic T cells (CD8+ T cells) directly kill infected or cancerous cells by inducing apoptosis. Helper T cells (CD4+ T cells) support other immune cells by releasing cytokines, which enhance the immune response.

T Cells and Pregnancy

During pregnancy, the immune system, including T cells, undergoes significant changes to protect the fetus while maintaining maternal health. Regulatory T cells (Tregs) play a critical role in preventing maternal immune cells from attacking the fetus, thus promoting tolerance and preventing complications such as pre-eclampsia and preterm birth.

Impact of T Cell Dysregulation

Dysregulation of T cell function can lead to various gynecological disorders. For example, an overactive or misdirected T cell response can contribute to autoimmune diseases like endometriosis and polycystic ovary syndrome (PCOS). Conversely, a weakened T cell response can result in increased susceptibility to infections and reduced cancer surveillance.

T Cells in Cancer Immunotherapy

Recent advances in cancer immunotherapy have leveraged T cells to target and eliminate gynecological cancers. Checkpoint inhibitors and CAR-T cell therapy are examples of treatments that enhance the ability of T cells to recognize and destroy cancer cells. These therapies have shown promise in treating cancers such as cervical cancer and endometrial cancer.

Future Directions

Ongoing research aims to better understand the role of T cells in gynecological health and disease. This includes exploring new therapeutic strategies to modulate T cell function, enhancing vaccine efficacy for STIs, and developing personalized immunotherapies for gynecological cancers. Understanding the complex interactions between T cells and the female reproductive system holds potential for improving women's health outcomes.

Relevant Publications

Investigation of Protein Lysine Acetylation in Antiviral Innate Immunity.

Issue Release: 2025

Tetrastigma hemsleyanum polysaccharide combined with doxorubicin promote ferroptosis and immune function in triple-negative breast cancer.

Issue Release: 2024

Metabolomics analyses reveal the crucial role of ERK in regulating metabolic pathways associated with the proliferation of human cutaneous T-cell lymphoma cells treated with Glabridin.

Issue Release: 2024

A novel syphilis Treponema pallidum lipoprotein peptide antigen diagnostic assay using red cell kodecytes in routine blood centre column agglutination testing platforms.

Issue Release: 2024

PCCA variant rs16957301 is a novel AKI risk genotype-specific for patients who receive ICI treatment: Real-world evidence from All of Us cohort.

Issue Release: 2024

Differences in the DNA Methylome of T cells in Adults With Asthma of Varying Severity.

Issue Release: 2024

The CCL2-CCR4 Axis Promotes Regulatory T Cell Trafficking to Canine Glioma Tissues.

Issue Release: 2024

The diagnostic value of selected immune parameters in peripheral blood of dogs with malignant mammary tumours - a preliminary study.

Issue Release: 2024

Cataloging circulating CD3CD56 T cells through a series of stimulating (NKG2D, DNAM-1) and inhibitory (PD-1, TIGIT, and Tim-3) immune checkpoint receptors in women diagnosed with precancerous cervical lesions or invasive cervical carcinoma.

Issue Release: 2024

MRI features and tumor-infiltrating CD8 + T cells-based nomogram for predicting meningioma recurrence risk.

Issue Release: 2024

IRF4 impedes human CD8 T cell function and promotes cell proliferation and PD-1 expression.

Issue Release: 2024

Insights into microstructure and expression of markers of proliferation, apoptosis and T cells in the spleen of cattle egret (Bubulcus ibis).

Issue Release: 2024

Electromagnetic field-induced adaptive response in Schwann cells through DNA methylation, histone deacetylation, and oxidative stress.

Issue Release: 2024

Anti-LINGO-1 treatment restores myelination of corticospinal tract neurons and improves functional recovery after stroke.

Issue Release: 2024

Adipose stem cells drive T cell infiltration in obesity.

Issue Release: 2024

Second bone marrow transplantation into regenerating hematopoiesis enhances reconstitution of immune system.

Issue Release: 2024

Sialic acids on T cells are crucial for their maintenance and survival.

Issue Release: 2024

Establishment of a humanized mouse model using steady-state peripheral blood-derived hematopoietic stem and progenitor cells facilitates screening of cancer-targeted T-cell repertoires.

Issue Release: 2024

Unraveling the role of γδ T cells in the pathogenesis of an oncogenic avian herpesvirus.

Issue Release: 2024

Differential expression profiles and functional prediction of circular RNAs in lung cancer patients with chronic obstructive pulmonary disease: a pilot study.

Issue Release: 2024

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