Ductal Carcinoma In Situ (DCIS) - Gynecology

What is Ductal Carcinoma In Situ (DCIS)?

Ductal Carcinoma In Situ (DCIS) is a non-invasive breast cancer where abnormal cells are found in the lining of a breast duct but have not spread outside the duct to other tissues in the breast. It is considered the earliest form of breast cancer and is highly treatable.

How is DCIS Diagnosed?

DCIS is often detected during a mammogram screening before any symptoms appear. A suspicious area found on a mammogram may lead to further testing, such as a biopsy, to confirm the diagnosis. In some cases, an MRI may be used to get a clearer image of the breast tissue.

What are the Risk Factors for DCIS?

Several risk factors are associated with DCIS, including age (most common in women over 50), family history of breast cancer, certain genetic mutations like BRCA1 and BRCA2, and previous history of breast conditions. Lifestyle factors such as high-fat diet and sedentary lifestyle may also contribute.

What are the Treatment Options for DCIS?

Treatment options for DCIS typically include surgery and may involve radiation therapy and/or hormone therapy. Surgical options include lumpectomy (removal of the abnormal tissue) or mastectomy (removal of the entire breast). The choice of treatment depends on the size and location of the tumor, patient preference, and other health considerations.

What is the Prognosis for DCIS?

The prognosis for DCIS is generally very good, especially when detected early. The 5-year survival rate is nearly 100% when appropriately treated. However, if left untreated, DCIS can progress to invasive breast cancer, which has a more complicated prognosis.

Can DCIS be Prevented?

While there is no certain way to prevent DCIS, certain measures can reduce the risk. These include maintaining a healthy weight, engaging in regular physical activity, limiting alcohol consumption, and avoiding hormone replacement therapy after menopause. Regular screening and early detection are crucial for prevention and successful treatment.

How Does DCIS Relate to Gynecology?

DCIS is significant in the field of gynecology because gynecologists often play a critical role in early detection through routine breast exams and patient education. They may be the first healthcare providers to identify suspicious changes in the breast and refer patients to specialists for further evaluation and treatment. Additionally, understanding the impact of reproductive history and hormonal factors on breast cancer risk is an integral part of gynecological care.

Relevant Publications

Surgical outcomes and prognosis of HER2+ invasive breast cancer patients with a DCIS component treated with breast-conserving surgery after neoadjuvant systemic therapy.

Issue Release: 2024

Tubular Carcinoma of the Breast: The Possibility to Omit Sentinel Lymph Node Biopsy.

Issue Release: 2024

Digital Mammography (DM) vs. Dynamic Contrast Enhancement-Magnetic Resonance Imaging (DCE-MRI) in Microcalcifications Assessment: A Radiological-Pathological Comparison.

Issue Release: 2024

Senescent CAFs mediate immunosuppression and drive breast cancer progression.

Issue Release: 2024

Non-mass-type ductal carcinoma in situ of the breast on ultrasound: Features and pathological analysis.

Issue Release: 2024

Clinical and Imaging Characteristics of Contrast-enhanced Mammography and MRI to Distinguish Microinvasive Carcinoma from Ductal Carcinoma In situ.

Issue Release: 2024

Ductal carcinoma in situ of the breast: finding the balance between overtreatment and undertreatment.

Issue Release: 2024

Multi-omics portrait of ductal carcinoma in situ in young women.

Issue Release: 2024

Longitudinal assessment of real-world patient adherence: a 12-month electronic patient-reported outcomes follow-up of women with early breast cancer undergoing treatment.

Issue Release: 2024

Epigenetic activation of SOX11 is associated with recurrence and progression of ductal carcinoma in situ to invasive breast cancer.

Issue Release: 2024

Adenocarcinoma of anogenital mammary gland type arising from encapsulated papillary carcinoma: A rare vulvar tumor mimicking breast carcinoma.

Issue Release: 2024

Potential rapid intraoperative cancer diagnosis using dynamic full-field optical coherence tomography and deep learning: A prospective cohort study in breast cancer patients.

Issue Release: 2024

Mammography of suspicious calcifications among ductal carcinoma in situ and benign breast disease.

Issue Release: 2024

Baseline circulating tumor DNA predicts long-term survival outcomes for patients with early breast cancer.

Issue Release: 2024

New Frontiers in Breast Cancer Imaging: The Rise of AI.

Issue Release: 2024

Tailored radiation dose according to margin width for patients with ductal carcinoma in situ after breast-conserving surgery.

Issue Release: 2024

Management and risk of upgrade of atypical ductal hyperplasia in the breast: A population-based retrospective cohort study.

Issue Release: 2024

Imaging Changes and Outcomes of Patients Undergoing Active Monitoring for Ductal Carcinoma In Situ: Seven-Year Follow-up Study.

Issue Release: 2024

Determination of Factors Associated with Upstage in Atypical Ductal Hyperplasia to Identify Low-Risk Patients Where Active Surveillance May be an Alternative.

Issue Release: 2024

Lumpectomy without radiation for ductal carcinoma in situ of the breast: 20-year results from the ECOG-ACRIN E5194 study.

Issue Release: 2024

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