While transdermal patches are suitable for many women, they are not recommended for those with certain conditions: - History of Blood Clots: Women with a history of thromboembolic disorders should avoid estrogen-containing patches. - Liver Disease: Since the patch still delivers hormones that are metabolized by the liver, women with severe liver disease should avoid it. - Certain Cancers: Women with a history of estrogen-dependent cancers should consult their healthcare provider before using hormone patches.