To conduct a comprehensive literature search, it is essential to follow a systematic approach. Start by defining your research question using the PICO framework (Population, Intervention, Comparison, Outcome). Next, identify relevant keywords and synonyms. Utilize Boolean operators like AND, OR, and NOT to combine search terms effectively. Use filters to narrow down results by publication date, study type, and language. Finally, review the abstracts and full texts to ensure the studies meet your criteria.