Diagnosis involves a series of blood tests to measure:
VWF Antigen: Determines the amount of VWF in the blood. VWF Activity: Assesses the functionality of VWF. Factor VIII Levels: Since VWF protects Factor VIII, low levels can indicate a problem. Ristocetin Cofactor Activity: Measures how well VWF binds to platelets.
Genetic testing may also be employed to identify specific mutations associated with VWD.