The VDRL test involves drawing a small amount of blood from the patient. The blood sample is then mixed with an antigen, and the mixture is observed for clumping (flocculation), which indicates the presence of antibodies against *Treponema pallidum*. It is important to note that the VDRL test is a non-treponemal test, meaning it does not detect the bacterium itself but rather the antibodies produced in response to the infection.