neurosyphilis

How is Neurosyphilis Diagnosed?

Diagnosis of neurosyphilis involves a combination of clinical evaluation, laboratory testing, and imaging studies. Key diagnostic steps include:
Serologic tests for syphilis, such as the Rapid Plasma Reagin (RPR) test and Treponema pallidum particle agglutination (TP-PA) test
Lumbar puncture to analyze cerebrospinal fluid (CSF) for elevated white blood cells, protein levels, and the presence of treponemal antibodies
Neurological examination to assess cognitive function and motor skills
Imaging studies like MRI or CT scans to detect brain or spinal cord abnormalities

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