The diagnosis of celiac disease involves a combination of blood tests and a biopsy of the small intestine. Blood tests look for specific antibodies, such as anti-tissue transglutaminase (tTG) and endomysial antibodies (EMA). If these tests are positive, a biopsy is usually performed to confirm the diagnosis. Women experiencing unexplained gynecological issues, such as infertility or menstrual irregularities, should consider being tested for celiac disease.