How do Coagulation Factors Affect Menstrual Bleeding?
Menstrual bleeding involves the shedding of the endometrial lining, which is regulated by a balance between coagulation and anticoagulation mechanisms. Abnormalities in coagulation factors, such as Factor VIII or von Willebrand Factor, can lead to heavy menstrual bleeding. Women with clotting disorders often experience menorrhagia and may require treatment with hormone therapy or clotting factor concentrates.
