The Amsterdam Criteria I and II are used to identify families that might be affected by Lynch syndrome:
Amsterdam Criteria I: This set of criteria is focused solely on colorectal cancer. It requires three or more relatives with colorectal cancer, with one being a first-degree relative of the other two, spanning at least two generations, and at least one case diagnosed before the age of 50. Amsterdam Criteria II: This is more inclusive and considers extracolonic cancers, including endometrial cancer. It requires three or more family members with Lynch syndrome-related cancers (colorectal, endometrial, small bowel, ureter, or renal pelvis cancer), with similar conditions regarding the relationship between patients, generations, and age of diagnosis as the Amsterdam Criteria I.
