The use of antithyroid drugs during pregnancy requires careful consideration. Propylthiouracil (PTU) is generally preferred during the first trimester because it has a lower risk of causing birth defects compared to Methimazole. However, Methimazole may be used in the second and third trimesters. It is crucial to monitor thyroid levels closely and adjust dosages as needed to avoid hypothyroidism, which can also cause pregnancy complications.