Yes, antacids can interact with various medications. They can affect the absorption of certain drugs, such as antibiotics and iron supplements, reducing their effectiveness. Women taking prescription medications should discuss the use of antacids with their healthcare provider to prevent potential interactions. To minimize interactions, it is often recommended to take antacids at a different time than other medications. A common guideline is to take medications either 1-2 hours before or 2-4 hours after taking an antacid.