What is Bevacizumab (Avastin)?
Bevacizumab, known by its brand name
Avastin, is a monoclonal antibody that inhibits vascular endothelial growth factor (VEGF). VEGF is a signal protein that promotes the growth of new blood vessels. By blocking VEGF, bevacizumab can restrict the blood supply to tumors, thereby inhibiting their growth.
Advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer.
Platinum-sensitive recurrent ovarian cancer.
Platinum-resistant recurrent ovarian cancer.
What are the Benefits of Bevacizumab in Gynecologic Oncology?
Clinical trials have shown that bevacizumab can extend progression-free survival in patients with advanced ovarian cancer. It has been particularly beneficial in cases where the cancer is resistant to other treatments. By inhibiting angiogenesis, bevacizumab helps to starve the tumor of the nutrients and oxygen it needs to grow.
Hypertension
Proteinuria
Wound healing complications
Gastrointestinal perforations
Thromboembolic events
It is crucial to monitor patients closely for these adverse effects, especially those with a history of cardiovascular disease or other risk factors.
How is Bevacizumab Administered?
Bevacizumab is administered via intravenous infusion. The dosage and schedule can vary depending on the specific type and stage of cancer, as well as the individual patient's response to the treatment. It is usually given every 3 weeks in combination with chemotherapy, followed by maintenance therapy.
Recent history of severe hemorrhage
Uncontrolled hypertension
Recent surgery or serious wounds
Gastrointestinal perforation
A thorough medical history and evaluation are essential before initiating treatment.
Conclusion
Bevacizumab (Avastin) represents a significant advancement in the treatment of advanced and recurrent ovarian cancers in gynecology. While it offers considerable benefits, it is not without risks, and careful patient selection and monitoring are crucial for optimizing outcomes. For more detailed information, consulting with an oncologist specialized in gynecology is highly recommended.
